Immobile myosin-II plays a scaffolding role during cytokinesis in budding yeast
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چکیده
منابع مشابه
Immobile myosin-II plays a scaffolding role during cytokinesis in budding yeast
Core components of cytokinesis are conserved from yeast to human, but how these components are assembled into a robust machine that drives cytokinesis remains poorly understood. In this paper, we show by fluorescence recovery after photobleaching analysis that Myo1, the sole myosin-II in budding yeast, was mobile at the division site before anaphase and became immobilized shortly before cytokin...
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Budding yeast possesses one myosin-II, Myo1p, whereas fission yeast has two, Myo2p and Myp2p, all of which contribute to cytokinesis. We find that chimeras consisting of Myo2p or Myp2p motor domains fused to the tail of Myo1p are fully functional in supporting budding yeast cytokinesis. Remarkably, the tail alone of budding yeast Myo1p localizes to the contractile ring, supporting both its cons...
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Who would have thought that the motor domain of a motor was dispensable? Nonmuscle myosin II has long been implicated in providing the contractile force to constrict the actomyosin ring during cytokinesis. So it was quite a shock to learn that myosin II could promote ring assembly and constriction (albeit a bit more slowly than wild-type) without its motor-domain “head” in budding yeast! The ke...
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Asymmetric cell division, which includes cell polarization and cytokinesis, is essential for generating cell diversity during development. The budding yeast Saccharomyces cerevisiae reproduces by asymmetric cell division, and has thus served as an attractive model for unraveling the general principles of eukaryotic cell polarization and cytokinesis. Polarity development requires G-protein signa...
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 2013
ISSN: 1540-8140,0021-9525
DOI: 10.1083/jcb.201208030